An insight into brachycephalic dog health from The Kennel Club

The Kennel Club has hosted a unique webcast to discuss brachycephalic health and what can be done collaboratively to ensure a healthier future for dogs. Chaired by Kennel Club Chairman, Tony Allcock OBE, the webcast panel comprised Dr Jane Ladlow, European and Royal College Specialist in Small Animal Surgery and leading BOAS researcher; Bill Lambert, Head of Health and Welfare at the Kennel Club; and Charlotte McNamara, Health and Welfare Development Manager at the Kennel Club.

The panel discussed brachycephalic health, approaches across Europe, the need for a collaborative, evidence-based approach, including how the Respiratory Function Grading Scheme can help protect and improve the health of brachycephalic dogs now and in the future, and the importance of data collection and ongoing research into the complex Brachycephalic Obstructive Airways Syndrome (BOAS).

Further information about brachycephalic dog health, what the Kennel Club is doing and which tools and health screening is available to breeders can be found at: https://www.thekennelclub.org.uk/flatfaceddoghealth

To donate and support further research into brachycephalic dog health and BOAS, visit: https://uk.virginmoneygiving.com/charity-web/charity/displayCharityCampaignPage.action?charityCampaignUrl=BDH

The Dog Owners’ Handbook – a great (free) resource from the Kennel Club

The Kennel Club has recently published (online) a Dog Owners’ Handbook. It’s free and you can download it as a 74-page pdf file, as well.

It contains lots of good advice for novice owners and there’s information that more experienced owners will also benefit from.

KC Dog Owner Guide 2019

.

.

.

.

.

.

.

.

.

 

International Canine Health Awards 2019

The International Canine Health Awards returned for the seventh year to celebrate some of the world’s finest researchers and scientists whose work has had a positive impact on the health and wellbeing of dogs.

The 2019 awards were run by the Kennel Club Charitable Trust and included substantial cash prizes donated by Vernon and Shirley Hill of Metro Bank, to go towards new or continued research.

The awards ceremony took place on Thursday, 30th May in Windsor at the start of the 4th International Dog Health Workshop. Professor Steve Dean, Chairman of the Trustees, was master of ceremonies and offered apologies from Mr & Mrs Hill who were unable to be in Windsor, although they (and their dog Sir Duffield) sent a video message to all the attendees. Mr Hill said “We are proud to support these important awards again, to fund research that may transform canine and human health by encouraging the same visionary thinking and innovation that Metro Bank champions. At Metro Bank, ‘Dogs Rule’”.

The four categories for the International Canine Health Awards were:

  • International Prize in Canine Health for outstanding contribution in the field of canine health and welfare with a prize fund of £40,000 for future projects. The award was presented to Dr Danika Bannasch who is Professor of Population Health and Reproduction at the University of California, Davis.
    She has made significant contributions to our understanding of of the genetic basis of many genetic disorders. She has been responsible for the development of DNA tests for 7 canine diseases including hormonal defect hyperadrenocorticism and chondrodystrophy.
  • Lifetime Achievement Award with a £10,000 prize fund was won by Associate Professor Gary Johnson from the Department of Veterinary Pathology at the University of Missouri. The award citation said that Gary Johnson is proof that it isn’t necessary for a vet to wield a scalpel or dispense a medicine to make a difference to animal health. His work on canine genetic diseases is reckoned to have saved the lives of many more dogs than most practising vets will manage during their careers. His lab was one of the first to adopt whole genome sequencing and, from 153 whole genome sequences, has identified 83 heritable diseases.
  • Student Inspiration Awards were split into undergraduate and postgraduate, with a prize fund of £10,000 for the post-graduate and £5,000 for the undergraduate winner. The post-grad winner was Adrian Baez-Ortega from Cambridge University who has been working in the field of bioinformatics – the combination of biology and information technology. His recent work has been on the evolution of canine transmissible venereal tumours. The under-grad winner was Nivan Mamak from Edinburgh University. In 2018, her vacation project was an investigation of paroxysmal dyskinesia in a family of Golden Retrievers. These student prizes aid further education costs, the development of these young people’s careers, or support a further project.
  • Breed Health Coordinator Award – with a £1,000 prize fund, went to Liz Branscombe (Flat-coated Retriever BHC). Liz is a registered veterinary nurse and, as well as acting as BHC, is also one of the KC’s team of BHC Mentors who spends time helping other breeds with their breed health improvement work. As well as working with her breed, Liz says an important part of her role is to pass on information from the breed community to the vet profession, which she has done as an author of articles in the vet press and as a regular public speaker.

After the final award was presented, it was great to see one of last year’s students, Alice Denyer, return to talk about how her prize had helped with her studies and research over the past year. Proof indeed, of the impact these awards can have in the real world!

Steve Dean concluded the presentations with further congratulations to the winners and thanks to the awards judges and KC team who staged the event. He then invited the assembled International Dog Health Workshop attendees to stay for a buffet dinner and celebratory drinks.

Nearly 20 years of DNA testing – what can we learn?

Doctors Tom Lewis (KC) and Cathryn Mellersh (AHT) recently published an Open Access paper where they analysed trends in DNA testing for 8 autosomally recessive conditions in 8 breeds. A headline in the Vet Times said “Study reveals ‘fantastic work’ of DNA testing”. The sub-headline stated that “A study has revealed responsible breeders are reducing the number of pedigree dogs at risk of often painful and debilitating inherited diseases by around 90%”.

This paper is exactly the sort of great work we have come to expect from the KC’s Health Team and their partners at the Animal Health Trust. I believe it could be one of the most influential papers that might be published this year because of its potential to influence breed health policy and strategy, as well as the behaviour of breeders and buyers.

I don’t want to dwell on the detail of the research; you can read that for yourself, here: https://goo.gl/PiQmMF – I want to discuss how and why this paper might be important. The study covers the results of 8 DNA tests in 8 breeds for the period 2000 to 2017. 2 of the DNA tests applied to 2 breeds, resulting in 10 test+breed combinations. The key metric used to measure progress was the Mutation Frequency which is more useful than simply counting the number or calculating the proportions of Clear, Carrier and Affected dogs. It is calculated as [(2 x No. of Affected) + No. of Carriers]/(2 x No. of dogs with a known result).

Measures of progress

Previously, many reports on the progress of DNA testing have simply shown the proportion of Clear, Carrier and Affected dogs tested each year and that’s what we used to report in our Dachshund Annual Health Report. However, as tests become more established, the KC is able to deduce the status of untested dogs and assign their hereditary status. For many tests we are now able to identify Hereditary Clear, Hereditary Carrier and Hereditary Affected dogs based on test results from their parents. That still leaves a proportion of dogs in the KC database without known or deduced status and the researchers acknowledged this in their analysis but were able to calculate a “worst case” view of mutation frequency in each breed. Those of us reporting on DNA testing in our breed should be asking the KC Health Team for Hereditary results so we can give a more accurate picture of the impact being made. The difference can be quite significant, for example 50% of the test results for PRA-rcd4 in Gordon Setters were “Clear” in 2017 but, when hereditary status is taken into account, 95% of the breed was “Clear”. When you’re telling the story of what’s been achieved, that’s a big difference.

Another aspect of the paper is the data on trends in uptake and usage of DNA tests. For most breeds, unsurprisingly, the peak uptake of DNA tests was around the time it became commercially available and subsequently tailing off. The one exception to this was Exercise Induced Collapse in Labradors where use of the test has grown steadily since its launch. The peak around launch may reflect the fact that breed club communities are often actively involved in developing a test and are therefore keen to make use of it as soon as it becomes available. The challenge for all of us in breed clubs is how to educate and influence those outside our community to make use of these tests.

The paper also shows that there is an inverse relationship between the size of a breed and the take-up rate of tests. The slowest rate of increase occurred in the 2 numerically largest breeds, Labradors and Cockers. In smaller breeds, it’s more likely that breed clubs have influence over a higher proportion of breeders. The Labrador/Cocker effect may also be related to the split of working, show and pet breeders, making it more difficult to reach a more diverse group of owners. It may also be the case that, in breeds where multiple DNA tests exist, like Labradors (5 tests according to the KC) and Cockers (4 tests), it is more difficult to persuade breeders to make use of what might be seen as “yet another test”.

Another consideration related to uptake of a test is breeders’ perception of the need to use it. The severity of the condition, its age of onset and how widespread affected dogs are in the population are all factors that individual breeders will consider when prioritising whether or not to use a test. In some cases, breeders simply don’t want to know despite the seriousness of a condition and prefer to bury their heads in the sand. All of this gets me back on my change management hobby-horse; it’s important to communicate much more than just the launch or availability of a new test.

Wider implications?

In some cases, the launch of a new test could actually make things worse in a breed. The paper notes the evidence of selection – breeders intentionally avoiding producing affected puppies. In some breeds we have seen unhelpful selection strategies such as Affecteds or Carriers being removed from the breeding population completely, when they could quite safely be mated to Clear dogs. Another unhelpful approach is when people rush to use the small number of Clear stud dogs available and we may end up with the so-called Popular Sire Syndrome and all the adverse consequences that go with that. So, while DNA tests do indeed have the potential to prevent the breeding of more affected puppies, breeders must consider the bigger picture of genetic diversity. Reducing the gene pool makes it even more likely that hitherto unseen recessive mutations will “pop up” as undesirable health problems.

There are over 700 inherited disorders and traits in dogs, of which around 300 have a genetically simple mode of inheritance and around 150 available DNA tests. This tells us that we should not rely on DNA testing to solve the “problem” of diseases in pedigree dogs.

This new paper therefore gives the KC and breed clubs an opportunity to educate (or re-educate) owners and breeders on how DNA tests can be used within an overall breed health strategy. As well as celebrating the fantastic work done by so many committed breed enthusiasts, the messaging needs to be wider than “DNA testing improves dog health”.

I also wonder to what extent this paper might cause the KC to review its policies on the registration system, particularly given that there have long been calls for responsible breeders to be recognised for their commitment. It’s no good saying that’s what the ABS is for when so many good breeders have chosen not to join. Last year, Our Dogs wrote “A Manifesto for Change”, directed at the KC Board. Among other things, it said there was a need to address (or justify clearly) long-standing issues related to the registration system such as the ABS, DNA identification and the requirements for health testing. I hope the Lewis & Mellersh paper provides part of the evidence-base for those discussions.